What potential effects does substance abuse have on well-being?

Substance abuse can significantly decrease overall quality of life and impair relationships, which is reflected in the correct answer. Engaging in substance use can lead to detrimental physical and mental health effects, such as increased anxiety, depression, and cognitive impairments. These health issues can hinder one's ability to function effectively in everyday life, affecting personal and professional relationships.

Additionally, individuals may experience social isolation or conflict with loved ones, as substance abuse often leads to erratic behavior and prioritizing substances over relationships and responsibilities. This decline in personal well-being can manifest in various aspects of life, leading to a cycle of further deterioration in mental and physical health and strained social connections.

In contrast, the other options suggest positive outcomes that are often not associated with substance abuse. For example, improvement in mental clarity, enhanced social acceptance, and increased job productivity are generally unrealistic expectations in the context of substance abuse, as these substances often hinder cognitive functioning, lead to social isolation or stigma, and reduce overall work performance.